substance

noun

1. 1

   the real physical matter of which a person or thing consists

   DNA is the substance of our genes

2. 2

   a particular kind or species of matter with uniform properties

   shigella is one of the most toxic substances known to man

3. 3

   the idea that is intended

   What is the meaning of this proverb?

4. 4

   the choicest or most essential or most vital part of some idea or experience

   the gist of the prosecutor's argument

   the heart and soul of the Republican Party

5. 5

   what a communication that is about something is about

6. 6

   considerable capital (wealth or income)

   he is a man of means

7. 7

   material of a particular kind or constitution

   the immune response recognizes invading substances