pain

noun

1
a somatic sensation of acute discomfort
as the intensity increased the sensation changed from tickle to pain
2
something or someone that causes trouble; a source of unhappiness
washing dishes was a nuisance before we got a dish washer
a bit of a bother
3
emotional distress; a fundamental feeling that people try to avoid
the pain of loneliness
4
a bothersome annoying person
that kid is a terrible pain
5
a symptom of some physical hurt or disorder
the patient developed severe pain and distension

1
cause bodily suffering to and make sick or indisposed
2
cause emotional anguish or make miserable
It pains me to see my children not being taught well in school

Also useful for “pain”:Unscrambler— Turn loose letters into real words