defile

noun

1
spot, stain, or pollute
The townspeople defiled the river by emptying raw sewage into it
2
make dirty or spotty, as by exposure to air; also used metaphorically
The silver was tarnished by the long exposure to the air
Her reputation was sullied after the affair with a married man
3
place under suspicion or cast doubt upon
sully someone's reputation

Also useful for “defile”:Unscrambler— Rearrange the letters in “defile”